Imaging · study · 2026
Multi-omics uncovers the immune landscape and molecular signatures associated with antibody-dependent cellular cytotoxicity in SARS-CoV-2 clearance
Listed in NCBI GEO
The immune responses to SARS-CoV-2 infection, especially neutralizing antibody generation, have been extensively studied.
Description
Beyond direct neutralization, antibodies can eliminate infected cells through engagement with natural killer (NK) cells. However, the molecular and cellular mechanisms by which NK cells collaborate with infection-induced antibodies in vivo during SARS-CoV-2 clearance remain elusive.
Here, we analyzed a cohort of patients recovered from the initial SARS-CoV-2 infection to dissect the relationship between viral clearance and antibody-dependent cellular cytotoxicity (ADCC). We found that patients' plasma ADCC capacity was associated with a slower rate of viral clearance and the blood T follicular helper (Tfh) cluster. To elucidate the action of ADCC-inducing antibodies in SARS-CoV-2 infection, we isolated a monoclonal antibody (mAb) with strong ADCC activity.
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This ADCC-inducing mAb elicited a transcriptional program linked to viral RNA transcription and protein glycosylation. Furthermore, spatial transcriptomics analysis revealed enriched expression of several NK marker genes in discrete spots within the lungs of SARS-CoV-2-infected mice treated with the ADCC-inducing antibody. Consistently, human peripheral blood NK cells ligated with the ADCC-inducing antibody displayed evolutionarily conserved NK cell clusters, similar to those elicited in mice.
Together, our study elucidates the temporally coherent action of specific NK cell subsets and ADCC-inducing antibodies in controlling SARS-CoV-2 infection.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300023 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300023 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1278727 ncbi.nlm.nih.gov/bioproject/PRJNA1278727 ↗
project · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE300023 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |