Data · dataset · 2026
Cofilin1-driven cytoskeletal remodeling licenses pan-cancer CD8+ T cell immunotherapy responses
Listed in ScienceDB
This dataset contains processed single-cell RNA sequencing (scRNA-seq) data from 8 patients with urothelial carcinoma (UC) who received neoadjuvant tislelizumab (anti-PD-1 antibody) monotherapy prior to radical cystectomy.
Description
The study aimed to identify molecular determinants of immunotherapy response in solid tumors, with particular focus on tumor-intrinsic biomechanical regulators of CD8⁺ T cell-mediated cytotoxicity. Among the 8 patients, 3 achieved pathological response (responders, R) and 5 showed no significant response (non-responders, NR).
Tumor biopsies were collected prior to treatment initiation and processed for single-cell transcriptomic profiling.The capture of individual cells and the subsequent synthesis of complementary DNA (cDNA) were accomplished utilizing the Single Cell 3′ Library and Gel Bead Kit V2 (10X Genomics, catalog number 120267).
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.33142 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Cancer 65% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.33142 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:rna-seq | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |