The role of Voclosporin administration and Inmt TG in renal proximal tubules.

We next investigated a strategy for preventing the significant decrease in Inmt expression in proximal tubules induced by high‑dose Voc administration and I/R. Accordingly, we used transgenic (Tg) mice with proximal tubule-specific Inmt overexpression and comparatively analyzed the changes with WT mice.

Both WT and Tg mice were treated with high‑dose Voc, followed by I/R or sham operation for controls. Two experimental groups were campared using RNA-seq as follows: 1. I/R+WT+Voc (WT mice subjected to I/R and treated with high‑dose Voc)=WT+AKI, 2.