Omics · study · 2026
Single-cell ATAC-seq profiling of ARID1A-loss-associated chromatin accessibility heterogeneity in pancreatic cancer cells
Listed in NCBI GEO
This Series contains single-cell ATAC-seq datasets from clone-resolved and pooled perturbation experiments examining how ARID1A and other epigenetic modifiers influence chromatin-accessibility heterogeneity in pancreatic ductal adenocarcinoma cells.
Description
The datasets include the main 28-clone BxPC3 experiment, a large-scale pooled five-shRNA experiment, acute SMARCA4 degradation with AU-15330, and independent experiments in BxPC3, HPAC/HPAFII, SW1990, and SUIT-2 backgrounds.
PseuMO-Tag lineage barcodes were used to connect single-cell chromatin profiles to clonal identity.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347847 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347847 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1531507 ncbi.nlm.nih.gov/bioproject/PRJNA1531507 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE347847 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |