Omics · study · 2026
Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma [DNAseq]
Listed in NCBI GEO
We introduced hundreds of CRISPR–Cas9-mediated DNA double-strand breaks (DSBs) into glioblastoma stem-like cells and tracked chromatin, transcriptional, and structural changes over time.
Description
Long after the DSBs were repaired, we found durable reprogramming of chromatin conformation and gene expression, as well as emergence of structural variants. These findings suggest that DNA damage can induce stable non-genetic alterations in cancer cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301130 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301130 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1284096 ncbi.nlm.nih.gov/bioproject/PRJNA1284096 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE301130 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |