Omics · study · 2026
Transcriptomic analysis of Primary B-cell target genes upon infection with Epstein-Barr Virus (EBV) expressing wildtype (WT) or mutant Latent Membrane Protein 1 (LMP1)
Listed in NCBI GEO
RNA-seq was used to characterize the LMP1 mediated regulation of host B-cell gene regulation.
Description
We infected Primary B-cells with Bacterial Artificial Chromosome (BAC)-derived WT LMP1 or TES1 mutant or TES2 mutant or TES1/TES2 double mutant LMP1 expressing EBV. Samples were assessed for transcriptomics effect on the host B-cell landscape at D7 post-infection and D21 post-infection.Because the TES1m and DM infected B-cells donot survive past D21 post-infection, D21 samples included WT vs TES2minfected B-cells only.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324842 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324842 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1437158 ncbi.nlm.nih.gov/bioproject/PRJNA1437158 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE324842 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |