Omics · study · 2026
MTOR-dependent expression of SP1 promotes the tolerogenic function of dendritic cells by inducing IL10 expression
Listed in NCBI GEO
Dendritic cells (DCs) are central regulators of immune responses and tolerance.
Description
Although CTLA4-Ig has been reported to promote tolerogenic properties in DCs, the molecular mechanisms underlying this process remain incompletely understood. The aim of this study was to characterize the transcriptional programs associated with CTLA4-Ig-induced tolerogenic DCs.
Human monocyte-derived DCs from healthy donors were stimulated with LPS in the presence of either control IgG or CTLA4-Ig and subjected to RNA sequencing. Comparative transcriptomic analysis was performed to identify differentially expressed genes and pathways associated with CTLA4-Ig-mediated tolerogenic reprogramming.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335844 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335844 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1479698 ncbi.nlm.nih.gov/bioproject/PRJNA1479698 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE335844 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |