Table · dataset · 2026
<b>Supporting Data for Single and Combinational Immunotherapies to Overcome Isocitrate Dehydrogenase 1 Mutant Intrahepatic Cholangiocarcinoma</b>
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.25442/hku.33346545.v1
<p dir="ltr">This dataset accompanies a study characterising the immune microenvironment of IDH1-mutant intrahepatic cholangiocarcinoma (iCCA).
Description
By investigating the impact of the oncometabolite R-2HG on primary murine cells, novel immunotherapeutic strategies for IDH1-mutant iCCA were identified. The repository contains quantitative IDH1 expression data from engineered murine iCCA cell lines, along with proliferation, apoptosis, Treg proportion, and transcriptomic sequencing data from T cells co-cultured with IDH1-mutant cells or treated with R-2HG.
Additionally, data regarding the antigen presentation functionality of bone marrow-derived dendritic cells under R-2HG treatment, as well as tumour burden evaluations following STING agonist therapy, are included.</p>
Links
Where it is published
- DOI doi.org/10.25442/hku.33346545.v1 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Cancer cell biology · Cancer cell biology · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Molecular targets · Molecular targets · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science · Tumour immunology · Tumour immunology
- Inferred from text
- Cancer 65% · Sequencing 75%
Provenance · 2 source records, 36 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33346545 | 5 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33346545 | 4 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].anzsrc:field:320409 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Tumour immunology'] |
| concepts[field].anzsrc:field:320409 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Tumour immunology'] |
| concepts[field].anzsrc:field:321101 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer cell biology'] |
| concepts[field].anzsrc:field:321101 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Cancer cell biology'] |
| concepts[field].anzsrc:field:321108 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Molecular targets'] |
| concepts[field].anzsrc:field:321108 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Molecular targets'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[modality].local:modality:sequencing | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |