Omics · study · 2026
scRNA-seq data for nonunion fracture
Listed in NCBI GEO
This single-cell RNA-seq dataset profiles clinical fracture-healing tissues from patients with fracture nonunion and normally healed fracture controls.
Description
Eight human specimens were initially collected, including five fracture nonunion samples and three normally healed control samples. After quality-control and integration assessment, two nonunion samples (NUBF01 and NUBF03) were excluded from the final integrated analysis because of marked batch-related interference; the final analyzed dataset comprised three nonunion samples (NUBF02, NUBF04, NUBF05) and three control samples (G0531, G0601, G0607).
Cell-cell communication analysis prioritized fibroblast-to-osteoblast signaling and highlighted an enhanced LIF-(LIFR+IL6ST) interaction in nonunion tissue.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337700 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337700 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1489793 ncbi.nlm.nih.gov/bioproject/PRJNA1489793 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337700 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |