Omics · study · 2026
Single-Cell Transcriptomic Profiling of Male Zebrafish hypothalamus: Investigating the Impact of CCK1/CCK2 Knockout on hypothalamus Function
Listed in NCBI GEO
This study explores the effects of CCK1 and CCK2 knockout on the hypothalamus of male zebrafish using single-cell RNA sequencing (scRNA-seq).
Description
Two groups were analyzed: the CCK1/CCK2 knockout (KO) group and the wild-type (WT) group. hypothalamus tissues were dissociated into single cells, followed by RNA sequencing to examine changes in gene expression. The results show how CCK receptor loss impacts hypothalamus cell function and gene expression, providing insights into the role of CCK in zebrafish hypothalamus regulation and endocrine function.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296008 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296008 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1257303 ncbi.nlm.nih.gov/bioproject/PRJNA1257303 ↗
project · from NCBI GEO
- PubMed 42000711 pubmed.ncbi.nlm.nih.gov/42000711 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75% · Zoology 70%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE296008 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3109 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |