Quantitative transcriptome and proteome maps of classical nonclinical species [b1]

The increase of use of biologics and novel modalities, combined with the opportunities of alternative to in vivo experimental methods in safety evaluation of new therapeutics. A detailed understanding of expression levels in target tissues is essential to selecting nonclinical species with the highest translational potential.

We quantified the relative RNA and proteinlevels across more than 40 normal tissues and 5 nonclinical species several tissues in human. We identified patterns of cross-species and methodology relationships that can aid in the broader understanding of nonclinical experimental design. We observedexpression profile similarity across tissues that favors species similarity, except for select nervous system and immune tissues.