Omics · study · 2026
E Protein-Driven iNKT Subset Modulation Shapes Early Immune Responses during Influenza A Virus Infection.
Listed in NCBI GEO
IAV infection elicits a robust immune response including invariant natural killer T (iNKT) cells.
Description
Using mouse strains with normal iNKT numbers but altered subset representation (NKTWT vs NKTET-2), we show that NKTET-2 mice exhibit reduced weight loss, diminished neutrophil recruitment and inflammatory monocyte activation, and ~40% less HA+ infected lung area versus controls. Early lung expression of type I IFN–responsive genes (IFIT1, ISG15) and chemokines (CCL2, CXCL2) was lower in NKTET-2, whereas IFNλ was elevated.
Single-cell RNA-seq of sorted lung iNKT cells revealed that NKTET-2 favored adhesion/repair and iNKT17-like programs over NKTWT type 1 effector responses. Modulating iNKT subset balance may limit immunopathology while preserving antiviral defense in IAV.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306684 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306684 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1311815 ncbi.nlm.nih.gov/bioproject/PRJNA1311815 ↗
project · from NCBI GEO
- PubMed 42089345 pubmed.ncbi.nlm.nih.gov/42089345 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE306684 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |