Omics · study · 2026
Role of E2F Transcription Factor 1 in the Pathogenesis of Pulmonary Arterial Hypertension
Listed in NCBI GEO
Dysregulated transcriptional programs are central to pulmonary vascular remodeling in pulmonary arterial hypertension.
Description
This bulk RNA-seq submission includes primary human lung microvascular endothelial cells transduced with adenoviral E2F1 or control adenovirus and mouse whole-lung samples from tamoxifen-induced E2f1 iDKO and Egln1 iCKO cohorts. The data were generated to define E2F1-associated transcriptional programs in endothelial cells and in the Egln1-driven pulmonary hypertension model.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335785 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335785 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1479441 ncbi.nlm.nih.gov/bioproject/PRJNA1479441 ↗
project · from NCBI GEO
- PubMed 42465492 pubmed.ncbi.nlm.nih.gov/42465492 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE335785 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |