Omics · study · 2026
Single-nucleus RNA sequencing highlights endothelial and Muller cell ER stress in VLDLR-/- mouse retina
Listed in NCBI GEO
Retinal neovascularization is a major contributor to vision loss in diseases such as age-related macular degeneration and proliferative diabetic retinopathy.
Description
The Vldlr knockout (Vldlr−/−) mouse model, characterized by abnormal and leaky blood vessels, is a well-established model for studying neovascularization. In this study, we provide new insights into inner retinal function in Vldlr−/− mice using oscillatory potentials (OPs) and single-cell RNA sequencing (scRNA-seq) to analyze gene expression profiles, focusing on pathways involved in retinal neovascularization and function.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319256 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319256 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1422688 ncbi.nlm.nih.gov/bioproject/PRJNA1422688 ↗
project · from NCBI GEO
- PubMed 42725908 pubmed.ncbi.nlm.nih.gov/42725908 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319256 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |