Omics · study · 2026
Multicellular derived S100A8/A9 maintains megakaryocytes in an immature state in immune thrombocytopenia.
Listed in NCBI GEO
Immune thrombocytopenia (ITP) is a common acquired autoimmune bleeding disorder characterized by reduced platelet count.
Description
Impaired maturation of megakaryocyte (MK) plays an important role, although the exact mechanisms are not fully understood. In this study, we performed 10x Genomics single-cell sequencing (SC-seq) on bone marrow samples from ITP patients and validated the data through in vitro models of megakaryocyte generation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE275nnn/GSE275370 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275370 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1150558 ncbi.nlm.nih.gov/bioproject/PRJNA1150558 ↗
project · from NCBI GEO
- PubMed 41414965 pubmed.ncbi.nlm.nih.gov/41414965 ↗
publication · from NCBI GEO
- PubMed 42342716 pubmed.ncbi.nlm.nih.gov/42342716 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE275370 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |