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Omics · study · 2026

scRNA-seq reveals TMEM59 regulates microlgial phagocytosis in Alzheimer’s disease

Listed in NCBI GEO

Microglia-mediated clearance of amyloid-β (Aβ) is critical for Alzheimer’s disease (AD) progression, yet the molecular regulators participating in microglial phagocytosis remain incompletely understood.

Description

Here, we identify TMEM59 as a previously unrecognized regulator of microglial Aβ clearance.

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Expression profiling by high throughput sequencing · Mus musculus
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Life Sciences
Inferred from text
Disease 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE32425814 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:diseaseenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:single-cell-rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title