Omics · study · 2026
scRNAseq of MC38 mouse tumors reveals diverse functions of LMO7 in regulating tumor microenvironment
Listed in NCBI GEO
We have employed a single cell sequening approach using 10x Genomics scRNAseq to study the function of LIM domain only 7 (LMO7) in tumor microenvironment.
Description
LMO7 has been widely reported in recent years as an E3 ubiquitin ligase with a wide range of regulatory effects on macrophages and fibroblasts. Based on this characteristic, we used scRNA-seq of tumor tissues from wild-type and LMO7 knockout mice to further explore its regulatory effects on the tumor microenvironment.
The results showed that LMO7 could significantly inhibit the pro-inflammatory polarization phenotype and phagocytic potential of macrophages, as well as inhibit the killing effect of CD8+ T cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294033 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294033 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1247927 ncbi.nlm.nih.gov/bioproject/PRJNA1247927 ↗
project · from NCBI GEO
- PubMed 41208232 pubmed.ncbi.nlm.nih.gov/41208232 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 69% · Cancer 65% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE294033 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |