Omics · study · 2026
Longitudinal single-cell RNA sequencing of PBMCs from a Guillain–Barré syndrome patient before and after IVIg treatment
Listed in NCBI GEO
Peripheral blood mononuclear cells (PBMCs) were collected longitudinally from a patient with Guillain–Barré syndrome (GBS) before and after intravenous immunoglobulin (IVIg) treatment.
Description
Single-cell RNA sequencing was performed to characterize treatment-associated immune remodeling at single-cell resolution. The study identified stage-dependent transcriptional changes in plasma cells, monocytes, B cells, and double-negative T cells, revealing alterations in inflammatory, humoral, and cytokine-mediated immune pathways.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334853 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334853 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1476622 ncbi.nlm.nih.gov/bioproject/PRJNA1476622 ↗
project · from NCBI GEO
- PubMed 42661746 pubmed.ncbi.nlm.nih.gov/42661746 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Longitudinal study 65% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE334853 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:longitudinal-study | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |