Omics · study · 2026
Single-cell RNA sequencing of age dependent responses to combination senolytic therapy in murine post-traumatic osteoarthritis
Listed in NCBI GEO
Osteoarthritis (OA) is characterized by progressive joint degeneration, with senescent cells contributing to disease pathology.
Description
This study investigates how aging influences the therapeutic response to senolytic interventions in post-traumatic osteoarthritis. We performed single-cell RNA sequencing on cells isolated from murine knee joints 8 weeks after surgical induction of post-traumatic OA.
Young (10 wks) and aged (72 wks) mice were treated with vehicle control, local senolytic therapy (intra-articular Nutlin), or combination therapy (intra-articular Nutlin and systemic ABT-263), with age matched uninjured mice as controls. We profile the age-related differences in cell response to senolytic treatments.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308803 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308803 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1332732 ncbi.nlm.nih.gov/bioproject/PRJNA1332732 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308803 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |