Data · dataset · 2025
Single-cell multimodal sequencing data from: Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4-r cases
Listed in SciLifeLab Data Repository
<p dir="ltr">This dataset contains single-cell multimodal data (scRNA-, scBCR-, and scADT-seq) for twenty-three cases of childhood BCP-ALL, including four samples each of BCR::ABL1-positive, ETV6::RUNX1-positive, and HeH, together with eleven samples of DUX4-rearranged ALL.
Description
In addition, the datset contains 9 samples of mononuclear cells, sorted CD34+ (n=3), CD19+ (n=3), and unsorted (n=3), from five normal bone marrow from healthy donors.
The dataset is available as raw sequencing reads (fastq; restricted access) or as an annotated multimodal dataset (h5ad). Cells from bone marrow were used for single-cell library preparation, according to the manufacturer’s protocol (10X Genomics CG000208: Chromium Next GEM Single Cell V(D)J Reagent Kits v1.1). The libaries were sequenced on a Novaseq 6000.</p>
Links
Where it is published
- DOI doi.org/10.17044/scilifelab.23592270.v1 ↗
DOI / persistent id · from figshare scilifelab se
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare scilifelab se
Topics
- From keywords
- Cancer genetics · Earth & Environmental Science · Life Sciences · Medicine & Health
- Inferred from text
- Sequencing 75%
Related
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| SciLifeLab Data Repository | oai:figshare.com:article/23592270 | 83 min ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].anzsrc:field:321103 | mapping · figshare scilifelab se | vocabulary-mapper@1.0.0 | keywords['Cancer genetics'] |
| concepts[field].local:field:earth-environmental | mapping · figshare scilifelab se | connector:figshare_scilifelab_se@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare scilifelab se | connector:figshare_scilifelab_se@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare scilifelab se | connector:figshare_scilifelab_se@1.0.0 | |
| concepts[modality].local:modality:sequencing | enrichment · figshare scilifelab se | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · figshare scilifelab se | connector:figshare_scilifelab_se@1.0.0 | /metadata/dc/description |
| license_text | source · figshare scilifelab se | connector:figshare_scilifelab_se@1.0.0 | |
| publication_date | source · figshare scilifelab se | connector:figshare_scilifelab_se@1.0.0 | |
| title | source · figshare scilifelab se | connector:figshare_scilifelab_se@1.0.0 | /metadata/dc/title |