Omics · study · 2026
Oxytocin is required for normal milk fat production
Listed in NCBI GEO
We used single-nucleus RNA-seq to examine the heterogeneity of lactating mammary glands (MGs) and the transcriptional profiles of mammary epithelial cells (MECs) in control and adipocyte-specific oxytocin receptor knockout (OxtrΔAd) mice.
Description
Our analysis identified all expected MG cell types, including MECs, myoepithelial cells, adipocytes, adipose progenitors, hormone-sensing progenitors, vascular, and immune cells. Notably, OxtrΔAd MGs exhibited a profound metabolic shift in MECs, characterized by reduced mTOR signaling, increased autophagy, and decreased lipid synthesis.
These findings underscore the essential role of OXT-driven adipose lipolysis in supporting lactation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289680 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289680 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1223937 ncbi.nlm.nih.gov/bioproject/PRJNA1223937 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE289680 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |