Omics · study · 2026
Paradoxical Oncogenic Effects of Hepatic Brca1 through Modulating Bhmt
Listed in NCBI GEO
Using 10x Genomics single nuclear RNA sequencing (snRNA-seq) to characterize differences between mice with and with Brca1 specifically in the liver, after carcinogen exposure.
Description
Hepatocellular carcinoma (HCC) is among the most common and deadly cancers worldwide and HCC-associated cases and deaths are projected to increase. Recently, tumor suppressor gene Breast cancer susceptibility gene 1 (BRCA1) was implicated in liver tumor development, yet its mechanisitc role remains unclear.
We found that hepatic Brca1 deficiency in mice paradoxically protected against carcinogen induced liver tumor development. Using snRNAseq, we sought to characterize differences in non-tumor liver tissue to determine the underlying mechanism driving liver tumor protection.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE322nnn/GSE322622 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE322622 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1430740 ncbi.nlm.nih.gov/bioproject/PRJNA1430740 ↗
project · from NCBI GEO
- PubMed 41781465 pubmed.ncbi.nlm.nih.gov/41781465 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE322622 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |