Excel · study · 2026
Pharmaco-behavioral Profiling Identifies Suppressors of Autism Gene-Associated Phenotypes in Zebrafish
Listed in NCBI GEO
In this study, we establish a pharmaco-behavioral database of behavioral signatures of 520 U.S. FDA-approved drugs using high-throughput assays of basic sensory processing and arousal behaviors in larval zebrafish and define highly conserved effects of common psychotropic medication targets.
Description
By leveraging the behavioral profiles of nine large-effect ASD gene mutants, we identify enrichment of pharmacological mechanisms that anti-correlate with subgroups of ASD genes informed by a precision medicine approach.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316340 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316340 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1402340 ncbi.nlm.nih.gov/bioproject/PRJNA1402340 ↗
project · from NCBI GEO
- PubMed 41838920 pubmed.ncbi.nlm.nih.gov/41838920 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Zoology 71%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316340 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3109 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |