Omics · study · 2026
Transcriptional control of Sulf1 by WT1 primes epicardial signalling and fate by modifying extracellular heparan sulfate status [scRNA-Seq]
Listed in NCBI GEO
Despite their decisive influence over the signalling that underlies cardiac morphogenesis, the expression of core HSPGs and the enzymes that give rise to distinct spatiotemporal sulfation patterning have not been well documented in the developing heart.
Description
In the present study, we systematically profiled 6-O-endosulfatases and target HSPGs expression in the embryonic mouse heart. We found that HSPGs are dynamically expressed, with cell-type specific expression, and changing tissue composition contributing to HSPG diversity in the developing embryonic heart.
We identified cell type-specific expression patterns for Sulf1 and Sulf2, that changed over the course of development, unrelated to lineage or embryonic origin. We reveal Sulf1 as the major 6-O-endosulfatase expressed in the epicardium.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299996 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299996 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1278676 ncbi.nlm.nih.gov/bioproject/PRJNA1278676 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Heart 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299996 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |