Dog-human gene network colocalization links synaptic signalling and ubiquitination to compulsive disorders

Combining dog and human GWAS implicates an inherited risk architecture largely outside current OCD pharmacotherapy and establishes pet dogs as a tractable model for psychiatric gene network discovery, particularly for conditions underpowered in human studies alone.</p><p dir="ltr">Data in storage includes Darwin's Ark genotype files:</p><ol><li>affy_round3 = Axiom Canine Array A+B with 1,011,992 SNPs, N = 411 mapped to CanFam3.1</li><li>DA_MERGED_GENCOVE_AXIOM_QC5 = 3328 dogs & 12518078 SNPs mapped to CanFam4.

Imputed with the Dog10K reference panel. Dataset is merged from Axiom Canine array (lifted and imputed, N=411) and Gencove low-pass sequencing (mapped to Cf4 and imputed, N=2917). This is the dataset before separating them into 17 dogCD phenotypes.</li><li>17 sets of sumstats (ITEM*sumstats & CCDF*_sumstats) from the GWAS of each items (N=14) and factor (N=3).</li><li>ALLFAM_sex_age_phenos.txt includes all phenotypes and covariates for dogs included in each separate plink gwas files (OBS for CCDF1 and CCF2: dogs with factor scores with only one item loading to that factor are excluded).</li></ol><p dir="ltr"><br></p>