Omics · study · 2026
Immune remodeling after thymectomy in patients with anti-AChR antibodies
Listed in NCBI GEO
We performed single-cell RNA sequencing (scRNA-seq) and T cell receptor (TCR) sequencing of peripheral blood mononuclear cells (PBMCs) from anti-acetylcholine receptor (AChR) antibody–positive patients before and after thymectomy.
Description
Analysis of immune cell composition revealed a reduction in naïve T cell populations and an increase in CD56^dim NK cells following thymectomy. Transcriptional profiling identified activation-associated gene expression in T cells and substantial gene expression changes in monocyte subsets, including reduced expression of antigen presentation–related genes.
In addition, cell–cell communication analysis revealed changes in dominant signaling pathways, with differences observed in TNF-, resistin-, and IFNγ-related signaling between pre- and post-thymectomy samples. Together, these data provide a resource for understanding immune remodeling after thymectomy at single-cell resolution.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330576 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330576 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1464632 ncbi.nlm.nih.gov/bioproject/PRJNA1464632 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE330576 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |