Omics · study · 2026
Single-cell RNA sequencing of human hepatocellular carcinoma and adjacent non-tumour liver tissues reveals etiology-associated and etiology-independent tumour microenvironmental features
Listed in NCBI GEO
Hepatocellular carcinoma (HCC) arises in the context of diverse aetiological backgrounds, yet the extent to which the tumour microenvironment is shaped by aetiology-associated versus aetiology-independent programmes remains incompletely understood.
Description
This dataset was generated to support interrogation of the cellular architecture of human HCC and the surrounding liver microenvironment at single-cell resolution. By profiling tumour and adjacent non-tumour liver tissues, the study provides a resource for examining malignant, immune, stromal, and hepatic parenchymal cell populations, and for investigating shared and aetiology-linked features of the HCC tumour microenvironment.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326201 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326201 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1444132 ncbi.nlm.nih.gov/bioproject/PRJNA1444132 ↗
project · from NCBI GEO
- PubMed 42374019 pubmed.ncbi.nlm.nih.gov/42374019 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326201 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |