Omics · study · 2026
Fus-depleted oligodendrocytes reduce neuronal damage and Alzheimer’s disease progression in the AppNL-G-F mouse
Listed in NCBI GEO
Oligodendrocytes provide myelination and metabolic support to neurons, but their contribution to Alzheimer's disease (AD) progression remains incompletely understood.
Description
To investigate the molecular effects of oligodendrocyte-specific Fus deletion, we performed single-cell RNA sequencing of hippocampal cells from AppNL-G-F (AD), AppNL-G-F/ Fusfl/fl/Cnpcre/+ (AD/cKO), Fusfl/fl/Cnpcre/+ (cKO), and Fusfl/fl (WT) mice. This dataset defines cell type-specific transcriptional profiles of hippocampal cells and identifies transcriptional changes associated with oligodendrocyte-specific Fus deletion in the context of Alzheimer's disease.
These data provide a resource for investigating molecular pathways underlying oligodendrocyte function, glial interactions, and Alzheimer's disease pathogenesis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339460 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339460 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1498884 ncbi.nlm.nih.gov/bioproject/PRJNA1498884 ↗
project · from NCBI GEO
- PubMed 42403013 pubmed.ncbi.nlm.nih.gov/42403013 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE339460 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |