Omics · study · 2026
Impact of Mettl1 on the transcriptional landscape of mouse bone marrow cells at single-cell resolution [scRNA-seq]
Listed in NCBI GEO
This study investigates the impact of Mettl1 deletion on the transcriptional landscape of bone marrow cells at single-cell resolution.
Description
Bone marrow mononuclear cells (BM MNCs) were collected from Mettl1+/+ Mx1-Cre and Mettl1fl/fl Mx1-Cre mice following poly(I:C)-induced recombination. Single-cell RNA sequencing (scRNA-seq) was performed using the 10x Genomics Chromium platform.
The resulting data were used to identify distinct cell populations, and assess transcriptional changes associated with Mettl1 loss. This dataset provides a valuable resource for understanding the role of Mettl1 in normal hematopoiesis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316206 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316206 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1401806 ncbi.nlm.nih.gov/bioproject/PRJNA1401806 ↗
project · from NCBI GEO
- PubMed 42247311 pubmed.ncbi.nlm.nih.gov/42247311 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316206 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |