Table · dataset · 2026
Data for Omar-Hmeadi et al PNAS 2026
Listed in ZivaHub and HKU DataHub and figshare and Loughborough Research Repository and UP Research Data Repository — shown once because both records carry DOI 10.6084/m9.figshare.34022250.v1
<p dir="ltr">Somatostatin secretion from pancreatic δ-cells inhibits nearby α- and β-cells, and tunes the body’s glycemic set-14 point.
Description
The role of δ-cells in diabetes remains unclear, in part due to the difficulty separating intrinsic regulation 15 from intra-islet paracrine effects. Here we compared the function of isolated δ-cells of cadaveric non-diabetic and 16 type-2 diabetic donors, by single cell TIRF-microscopy, electrophysiology, and secretion measurements.
Elevated 17 glucose stimulated exocytosis of somatostatin, which was further amplified by glucagon, exendin-4, or forskolin, 18 independent of diabetic status. GABA enhanced exocytosis and electrical activity, while insulin had no detectable 19 effect. Adrenaline and somatostatin strongly inhibited δ-cell activity, leading to autocrine feedback inhibition of 20 somatostatin exocytosis.
Read the rest (1 more)
In type-2 diabetes, δ-cell inhibition by somatostatin and adrenaline was impaired, 21 together with a marked reduction in somatostatin receptor (SSTR2) surface expression. The data suggest that 22 selective loss of inhibitory control of δ-cells may dysregulate intra-islet somatostatin signaling in type-2 diabetes.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.34022250.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Astronomy & Astrophysics · Cell metabolism · Cell metabolism · Cell metabolism · Cell metabolism · Cell metabolism · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Endocrinology · Endocrinology · Endocrinology · Endocrinology · Endocrinology · Engineering · Engineering · Engineering · Humanities · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Signal transduction · Signal transduction · Signal transduction · Signal transduction · Signal transduction · Social Science · Social Science · Social Science
Provenance · 5 source records, 52 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34022250 | 7 d ago | JSON v1 |
| HKU DataHub | oai:figshare.com:article/34022250 | 7 d ago | JSON v1 |
| figshare | oai:figshare.com:article/34022250 | 6 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/34022250 | 6 d ago | JSON v1 |
| UP Research Data Repository | oai:figshare.com:article/34022250 | 6 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:310103 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Cell metabolism'] |
| concepts[field].anzsrc:field:310103 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Cell metabolism'] |
| concepts[field].anzsrc:field:310103 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Cell metabolism'] |
| concepts[field].anzsrc:field:310103 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Cell metabolism'] |
| concepts[field].anzsrc:field:310103 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell metabolism'] |
| concepts[field].anzsrc:field:310111 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Signal transduction'] |
| concepts[field].anzsrc:field:310111 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Signal transduction'] |
| concepts[field].anzsrc:field:310111 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Signal transduction'] |
| concepts[field].anzsrc:field:310111 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Signal transduction'] |
| concepts[field].anzsrc:field:310111 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Signal transduction'] |
| concepts[field].anzsrc:field:320208 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Endocrinology'] |
| concepts[field].anzsrc:field:320208 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Endocrinology'] |
| concepts[field].anzsrc:field:320208 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Endocrinology'] |
| concepts[field].anzsrc:field:320208 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Endocrinology'] |
| concepts[field].anzsrc:field:320208 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Endocrinology'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |