Omics · study · 2026
Single-Cell Transcriptomic Profiling of Male Zebrafish Pituitary: Investigating the Impact of CCK1/CCK2 Knockout on Pituitary Function
Listed in NCBI GEO
This study explores the effects of CCK1 and CCK2 knockout on the pituitary of male zebrafish using single-cell RNA sequencing (scRNA-seq).
Description
Two groups were analyzed: the CCK1/CCK2 knockout (KO) group and the wild-type (WT) group. Pituitary tissues were dissociated into single cells, followed by RNA sequencing to examine changes in gene expression.
The results show how CCK receptor loss impacts pituitary cell function and gene expression, providing insights into the role of CCK in zebrafish pituitary regulation and endocrine function.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295139 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295139 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1253617 ncbi.nlm.nih.gov/bioproject/PRJNA1253617 ↗
project · from NCBI GEO
- PubMed 42000711 pubmed.ncbi.nlm.nih.gov/42000711 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE295139 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |