Omics · study · 2026
A Postnatal Chondro-Hematopoietic Axis Generates Functional Hematopoietic Stem Cells via Endothelial Transition
Listed in NCBI GEO
Conventional understanding holds that definitive hematopoietic stem cells (HSCs) form only during embryogenesis and subsequently colonize bone marrow (BM).
Description
We challenge this by identifying a postnatal source of HSCs within the epiphyseal cartilage. Using multimodal fate-mapping, we show that hypertrophic chondrocytes transdifferentiate into vascular endothelial cells.
Single-cell RNA sequencing reveals a continuous developmental path from these chondrocyte-derived endothelial cells to HSCs via a hemogenic intermediate. This endothelial-to-hematopoietic transition (EHT) generates functional stem and progenitor cells crucial for initial formation of the secondary BM. The process peaks during early niche assembly and declines upon colonization by external HSCs.
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Transplantation experiments confirm the cell-autonomous capacity of cartilage to establish a full vascular-hematopoietic niche. Our findings redefine hematopoietic development by revealing a postnatal chondro-hematopoietic axis and an extraordinary plastic potential of chondrocytes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326052 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326052 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1443220 ncbi.nlm.nih.gov/bioproject/PRJNA1443220 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326052 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |