Omics · study · 2026
Single-nucleus RNA-seq of mouse cortex following CCI-induced traumatic brain injury across multiple time points
Listed in NCBI GEO
This dataset provides single-nucleus transcriptomic profiles of mouse cortex following controlled cortical impact (CCI)-induced traumatic brain injury (TBI) across multiple time points, including control, 6 hours, 2 days, and 4 days.
Description
It enables the investigation of dynamic, cell-type-specific transcriptional responses during injury progression, including immune activation, oligodendrocyte lineage changes, and neuronal responses.
The dataset can be used to explore molecular mechanisms associated with brain edema and to facilitate cross-species comparisons with human TBI, helping to identify conserved and species-specific injury programs.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277487 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277487 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1162272 ncbi.nlm.nih.gov/bioproject/PRJNA1162272 ↗
project · from NCBI GEO
- PubMed 42203771 pubmed.ncbi.nlm.nih.gov/42203771 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE277487 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |