Table · dataset · 2026
<b>An Integrated Bioinformatics-Experimental Framework Reveals the Mitochondrial-Ferroptosis Axis in Sarcopenia Pathogenesis</b>
Listed in figshare
<p dir="ltr">Bulk transcriptomic profiles were combined with single-cell RNA sequencing data.
Description
Differentially expressed genes were overlapped with MitoCarta3.0 mitochondrial-related genes and ferroptosis-related genes. Random forest, support vector machine, and LASSO models were applied for feature selection and cross-dataset validation.
Functional enrichment, immune infiltration, regulatory network construction, and single-cell trajectory analyses were conducted. C2C12 myoblast assays were used to validate mitochondrial injury associated with ferroptosis.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.33736081.v1 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Computer Science & AI · Earth & Environmental Science · Economics & Finance · Engineering · Genomics and transcriptomics · Humanities · Life Sciences · Machine learning · Medicine & Health · Ocean & Atmospheric Science · Social Science
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 21 field assertions
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|---|---|---|---|
| figshare | oai:figshare.com:article/33736081 | 10 d ago | JSON v1 |
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| concepts[field].anzsrc:group:4611 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Machine learning'] |
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| concepts[modality].local:modality:rna-seq | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
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| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |