Omics · study · 2026
Aortic Single-Cell Transcriptome Analysis Reveals ApoE Isoform-Specific Effects in Vascular Disease Modulation
Listed in NCBI GEO
The human APOE gene is polymorphic with 3 major alleles that encode apolipoprotein (apo) E2, apoE3, and apoE4.
Description
Both apoE2 and apoE4 are associated with increased atherosclerosis risk. This study uses Human APOE2, APOE3, and APOE4 gene replacement mice and scRNA-seq to delineate the mechanisms underlying this association, with a focus on how the various apoE isoforms influence the cell repertoire in the vessel wall.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314969 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314969 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1393366 ncbi.nlm.nih.gov/bioproject/PRJNA1393366 ↗
project · from NCBI GEO
- PubMed 42353333 pubmed.ncbi.nlm.nih.gov/42353333 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314969 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |