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Omics · study · 2026

Single-cell transcriptomic profiling of endothelial cells across four developmental stages of zebrafish larvae

Listed in NCBI GEO

The vascular endothelium, once considered a simple passive barrier, is now recognized as a highly dynamic and heterogeneous tissue that plays a crucial role in organ homeostasis, immunity, and disease pathogenesis.

Description

We performed scRNA-seq to systematically profile zebrafish endothelial cells at 1, 2, 4, and 8 dpf, mapping their developmental progression at single-cell resolution. This study delineates the transition of ECs from early specification to functional specialization, and defined distinct EC subpopulations during early ontogeny.

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Danio rerio · Expression profiling by high throughput sequencing
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Life Sciences
Inferred from text
Disease 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE32727214 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:diseaseenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:single-cell-rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:7955source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title