Omics · study · 2026
Periostin Defines a Pathological Fibroblast Program Enriched in Restrictive Allograft Syndrome
Listed in NCBI GEO
Chronic lung allograft dysfunction (CLAD) is the major limitation to long-term survival after lung transplantation and includes distinct clinical phenotypes such as bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS).
Description
To define fibroblast states associated with CLAD phenotypes, we performed single-cell RNA sequencing of dissociated human lung tissue obtained from explanted lung allografts. Integrated analysis identified a periostin (POSTN)-associated pathological fibroblast program enriched in RAS compared with BOS and control lungs.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325801 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325801 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1441654 ncbi.nlm.nih.gov/bioproject/PRJNA1441654 ↗
project · from NCBI GEO
- PubMed 42579794 pubmed.ncbi.nlm.nih.gov/42579794 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE325801 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |