Omics · study · 2026
Aberrant epithelialization: A plausible factor for the development of endometrial polyps [scRNA-seq]
Listed in NCBI GEO
To explore cellular heterogeneity and differentiation trajectories in endometrial polyps (EPs), single-cell RNA sequencing was performed on five EP and four adjacent endometrial tissue (adEN) samples using the 10x Genomics platform (targeting ~5,000 cells per sample).
Description
Clustering analysis identified eight major cell types, including stromal, epithelial, endothelial, immune, perivascular, macrophage, B cells, and ciliated cells.
Pseudotime trajectory reconstruction revealed altered stromal-to-epithelial transitions in EPs with intermediate clusters enriched for MECOM and EYA2, suggesting aberrant epithelial maturation and disrupted vascular remodeling as potential mechanisms underlying EP formation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305281 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305281 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1304983 ncbi.nlm.nih.gov/bioproject/PRJNA1304983 ↗
project · from NCBI GEO
- PubMed 41712676 pubmed.ncbi.nlm.nih.gov/41712676 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE305281 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |