Omics · study · 2026
Molecular Mechanism of Oncostatin M-Mediated Bronchopulmonary Dysplasia Induced by Intrauterine Inflammation [scRNA-seq]
Listed in NCBI GEO
Intrauterine inflammation is a key risk factor for bronchopulmonary dysplasia (BPD) in preterm infants, though mechanisms remain unclear.
Description
We found that intrauterine inflammation activates fetal pulmonary macrophages, which upregulate Oncostatin M (OSM) via Junb. OSM then induces alveolar epithelial cell senescence through the Atf3-p21 signaling pathway, resulting in developmental lung injury.
This study identifies a novel macrophage-OSM-epithelial senescence axis in BPD pathogenesis, offering potential therapeutic targets.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311141 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311141 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1368721 ncbi.nlm.nih.gov/bioproject/PRJNA1368721 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Single-cell RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE311141 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |