ELF5 regulates epithelial integrity independently of EHF [ChIP-seq]

The ELF5 gene maps to chr11p13 where it is located adjacent to another epithelial ETS factor gene, ETS homologous factor (EHF). This genomic interval is associated with lung disease.

The functions of ELF5 in the airway epithelium are not well studied, in large part due to a lack of cellular models expressing the gene. Using scRNA-seq data from primary human bronchial (HBE) and nasal (HNE) epithelial cells we show ELF5 expression in subsets of ciliated and secretory cells, implicating a role for this factor in the airway epithelium. Next, we generate cistrome and transcriptome data for ELF5 in another epithelial cell type with abundant ELF5, and use bioinformatic tools to reveal the potential functions of this factor in the airway epithelium.