Omics · study · 2026
Single cell RNA-sequencing across striatal subregions and cell types in early-grade Huntington’s disease and controls [snRNA-Seq]
Listed in NCBI GEO
The molecular mechanisms that underlie striatal subregional and cell subtype-specific vulnerabilities and the cascade of molecular events occurring during Huntington’s disease remain poorly defined.
Description
Gene expression libraries from early-grade Huntington’s disease striatum across two striatal subregions were profiled and compared to controls to understand dynamics of cell loss and transcriptional dysregulation. These data identify dorsal-biased vulnerability to MSN cell loss and transcriptional dysregulation, characterize resilient MSN subtypes (D1 interface MSNs), determine a spatial dorsolateral-ventromedial axis of vulneraiblity, and define principles of MSN de-repression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327450 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327450 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1450961 ncbi.nlm.nih.gov/bioproject/PRJNA1450961 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327450 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |