Omics · study · 2026
Tet2 deficiency alters CD4+ T-cell function and promotes T-cell lymphoma with a TFH-cell immunophenotype.
Listed in NCBI GEO
TET2 mutations are frequent in TFH derived lymphomas, but how epigenetic disruption initiates malignant T cell transformation is unclear.
Description
We performed CRISPER mediated TET2-knockout in normal human CD4+ T cells and culture them long term. We perfromed scRNAseq after 40 or 90 days or long-term culture (>200 days).
ScRNA-seq revealed a persistent proliferative cluster characterized by elevated stem like transcriptional features compared to wild type counterparts
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319667 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319667 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1424941 ncbi.nlm.nih.gov/bioproject/PRJNA1424941 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Single-cell RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319667 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |