Omics · study · 2026
Dysregulated ClpP Activation Depletes AML Cells and Restores T-cell Function via Metabolic Competition
Listed in NCBI GEO
We employed single-cell RNA sequencing (scRNA-seq) to investigate immune responses in a syngeneic acute myeloid leukemia (AML) model generated by transplantation of murine WEHI-3-luc cells into BALB/c mice.
Description
Treatment with the novel CLPP inhibitor IMP125 (5 mg/kg) demonstrated superior therapeutic effects compared with ONC201, lower-dose IMP125, and conventional chemotherapy agents, including reductions in leukemic burden, prolonged survival, and enhanced immune activation.
Spleen, bone marrow, and liver tissues were profiled to provide insights into the immune mechanisms underlying IMP125 efficacy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306851 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306851 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1312529 ncbi.nlm.nih.gov/bioproject/PRJNA1312529 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE306851 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |