scRNA-seq of vascular endothelial cells from multiple mouse tissues and human limb muscle

We demonstrate that CD157-positive ECs exhibit a conserved transcriptional profile across tissues, including gene signatures associated with angiogenesis. By integrating mouse and human scRNA-seq datasets, we identified EC clusters in human tissue that display gene expression profiles similar to those of mouse CD157-positive ECs.

These cells were localized to the intima of large vessels and were found to express newly identified, specific marker genes.