Table · dataset · 2026
Table_1_The Interaction of CDH20 With β-Catenin Inhibits Cervical Cancer Cell Migration and Invasion via TGF-β/Smad/SNAIL Mediated EMT.DOCX
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fonc.2019.01481.s001
<p>Cancer-associated cadherin 20 (CDH20) is a novel identified cadherin that is genetically altered in several types of human cancer, including cervical cancer.
Description
However, its involvement in the progression of cervical cancer remains unknown. In this study, we show that CDH20 was downregulated in clinical cervical cancer samples and its expression correlated with cervical cancer clinical features.
CDH20 negatively regulated the migration and invasion of cervical cancer cells. CDH20 increased the expression and promoted the cytoplasm and membrane translocation of β-catenin, and interacted with β-catenin. Mechanistically, CDH20/β-catenin suppressed transforming growth factor-β (TGF-β)-induced epithelial-to-mesenchymal transition (EMT) by downregulating Snail through reducing the phosphorylation and nuclear translocation of Smad2/3.
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Taken together, our data suggest that CDH20 may act as a tumor suppressor that interacts with β-catenin to inhibit cervical cancer cell migration and invasion via TGF-β/Smad/Snail mediated EMT.</p>
Links
Where it is published
- DOI doi.org/10.3389/fonc.2019.01481.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Cancer · Cancer · Cancer cell biology · Cancer cell biology · Cancer diagnosis · Cancer diagnosis · Cancer genetics · Cancer genetics · Chemistry · Chemistry · Chemotherapy · Chemotherapy · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Haematological tumours · Haematological tumours · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Molecular targets · Molecular targets · Ocean & Atmospheric Science · Psychology & Behavioral Science · Radiation therapy · Radiation therapy · Social Science · Social Science · Solid tumours · Solid tumours
Provenance · 2 source records, 46 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33994824 | 4 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33994824 | 4 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:field:321101 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer Cell Biology'] |
| concepts[field].anzsrc:field:321101 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Cancer Cell Biology'] |
| concepts[field].anzsrc:field:321102 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer Diagnosis'] |
| concepts[field].anzsrc:field:321102 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Cancer Diagnosis'] |
| concepts[field].anzsrc:field:321103 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer Genetics'] |
| concepts[field].anzsrc:field:321103 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Cancer Genetics'] |
| concepts[field].anzsrc:field:321105 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Chemotherapy'] |
| concepts[field].anzsrc:field:321105 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Chemotherapy'] |
| concepts[field].anzsrc:field:321106 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Haematological Tumours'] |
| concepts[field].anzsrc:field:321106 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Haematological Tumours'] |
| concepts[field].anzsrc:field:321108 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Molecular Targets'] |
| concepts[field].anzsrc:field:321108 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Molecular Targets'] |
| concepts[field].anzsrc:field:321110 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Radiation Therapy'] |
| concepts[field].anzsrc:field:321110 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Radiation Therapy'] |
| concepts[field].anzsrc:field:321111 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Solid Tumours'] |
| concepts[field].anzsrc:field:321111 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Solid Tumours'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |