25 datasets

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">This dataset contains molecular dynamics (MD) trajectory movies and associated cluster-resolved data for five flaviviral NS5–ligand complexes investigated using molecular dynamics, binding-site-guided conformational clustering, quantum mechanics/molecular mechanics (QM/MM) calculations, and local vibrational mode analysis (LMA).</p><p dir="ltr">The five systems are: (1) dengue virus (

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">Source data underlying the figures of the article "Salvage of host-derived geranylgeraniol limits fosmidomycin efficacy in murine Plasmodium berghei malaria" (Communications Biology, manuscript COMMSBIO-26-0835A).</p><p><br></p><p dir="ltr">The archive contains one folder per figure, with the numerical data underlying every graph in the main and supplementary figures, the correspondin

ZivaHub2026 · dataset

<p dir="ltr">Lung adenocarcinoma (LUAD) is highly heterogeneous, and the mechanisms linking gut microbiota-derived metabolites to tumor-associated transcriptional regulation remain unclear. We integrated two paired LUAD transcriptomic datasets, GSE40419 and GSE32863, to perform differential expression, functional enrichment, protein-protein interaction (PPI), and transcription factor (TF) activity

ZivaHub + HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">Primary sclerosing cholangitis (PSC) is a progressive cholangiopathy tightly linked to gut microbiota dysregulation via the gut-liver axis. While mesenchymal stromal cell (MSC) therapy holds promise for PSC, whether and how the gut microbiota mediates its efficacy remain unknown. Using Mdr2⁻/⁻ mice, we found that human placenta‑derived MSCs significantly alleviated PSC symptoms, reduc

ZivaHub + HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">病毒性心肌炎（VMC）是一种由病毒复制和宿主炎症反应共同驱动的炎症性心脏疾病。柯萨奇病毒B3（CVB3）是VMC的主要致病原体之一。目前的抗病毒疗法在纠正感染后免疫炎症失调和心肌修复障碍方面仍有限。以往的研究，包括我们的初步发现，已证明瓜氨酸对心血管菌感染具有抗病毒活性;然而，单用时其抗病毒疗效仍然相对有限。因此，在本研究中，我们旨在寻找能够增强瓜氨酸抗CVB3作用的抗病毒组合策略。 通过<i>外</i>筛查多种抗病毒化合物与瓜氨酸联合使用，硼比醇盐酸盐（AH）和利巴韦林（RBV）被确定为具有增强抗心血管蛋白活性的候选组合方案。 <i>体外</i>实验进一步表明，瓜氨酸与AH或RBV联合使用比单药更有效地抑制CVB3复制。在感染CVB3的小鼠中，联合AH和瓜氨酸治疗提高了生存率并缓解了心肌损伤。机制分析显示，这种组合与巨噬细胞极化逆转、肠道微生物稳态恢复相关，且有

ZivaHub + HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">This dataset contains processed single-nucleus RNA sequencing (snRNA-seq) data generated from heart tissues of coxsackievirus A6 (CVA6)-infected wild-type (WT) and Ifnar1-deficient mice. Heart tissues were collected at 5 days post-infection (dpi). Six independent biological samples were included, comprising three CVA6-infected WT mice and three CVA6-infected Ifnar1-deficient mice, wit

HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr"><b>Background</b>: Optimising sampling frames for genomic surveillance of <i>E. coli</i> and <i>Klebsiella </i>may support interventions to mitigate bloodstream infections (BSIs), but approaches to estimating sample size and how these relate to bacterial population diversity at multiple genetic levels (strain/plasmid/antimicrobial resistance genes</p><p dir="ltr">[ARGs]) are lacking.<

HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">In the era of antiretroviral therapy (ART), persistent immune activation and inflammation increase the risk of non-AIDS-related complications in people living with HIV (PLWH), representing a major challenge in AIDS treatment. HIV-1 infection disrupts cytokine network and plasma virome, yet the long-term impact of ART on them and their relationship with immune activation remain poorly

figshare + Loughborough Research Repository2026 · Astronomical catalogue

<p dir="ltr">This repository accompanies the systematic review “Pyomelanin in <i>Pseudomonas aeruginosa</i>: a systematic review of genetic architectures, evolutionary trade-offs and clinical relevance”. It contains study-level data extracted from 50 included studies, mapped-deletion data and the Supplementary Information.</p>

figshare2026 · Astronomical catalogue

<p dir="ltr">This repository contains the supplementary datasets generated during a doctoral research project investigating schistosome adhesion and lipid acquisition networks through comparative genomics, orthology analysis, domain architecture profiling, phylogenetics, and network-based target prioritisation. The collection includes curated protein catalogues, orthogroup assignments, phylogeneti

figshare2026 · Astronomical catalogue · restricted

<p dir="ltr"><i>Bacteroides</i> <i>fragilis</i> group (BFG) organisms are important members of the gut commensal flora and common anaerobic pathogens causing various infections. Traditionally, antimicrobial susceptibility patterns in BFG have been highly predictable, leading to generally good outcomes with empirical treatment. However, in recent years, resistance to several key anti-anaerobic drug

figshare2026 · Astronomical catalogue

<p dir="ltr">Differentiated normal human bronchial epithelial cells (NHBE) were infected with SARS-CoV (strain: HK39849) or SARS-CoV-2 (strain: hCoV-19/Hong Kong/VM0001061/ 2020) at an MOI of 0.5 or MOCK-infected with PBS, and were collected at 2h, 6h, 24h, 48h, and 72h post-infection (hpi) to determine viral load and host response by TCID50 and bulk RNA sequencing (RNAseq), respectively. Male Syr

figshare2026 · Astronomical catalogue

<p dir="ltr">Data set resistance</p><p dir="ltr"><br></p>

figshare2026 · Astronomical catalogue

<p dir="ltr">Dengue is a rapidly spreading disease transmitted by mosquitoes and is caused by the <i>Dengue virus</i> (DENV), affecting approximately 390 million individuals globally. The only vaccine approved by the FDA, Dengvaxia, has limited effectiveness and is not authorized for use in India. Tomatidine, a steroidal alkaloid obtained from <i>Solanum</i> species, has demonstrated broad-spectru

figshare2026 · Astronomical catalogue

<p dir="ltr">QFT-Plus assay results over three years using three different methodologies: ELISA-based testing and CLIA-based testing with either lyophilized or liquid conjugate formulations in routine clinical practice.</p>

figshare2026 · Astronomical catalogue

<p dir="ltr">Supplementary Materials for 'β-Lactamase Type, Multidrug Resistance and the Association with Virulence in Third-Generation Cephalosporin-Resistant <i>Klebsiella pneumonia</i><i>e</i>'</p>

figshare2026 · Astronomical catalogue

<p dir="ltr">This study compared the VITEK® REVEAL^TM fast AST system for direct testing from positive blood cultures (PBCs) with the standard-of-care VITEK® 2.A total of 250 prospectively collected PBC bottles containing monomicrobial Gram-negative organisms were assessed. AST was performed using VITEK® REVEAL^TM directly from PBC and VITEK® 2 from isolated colonies recovered

figshare2026 · Astronomical catalogue

<p dir="ltr">16srRNA sequencing. </p>

figshare2026 · Astronomical catalogue

<p dir="ltr">Data ser HPV and ITS</p>

DataCite2026 · dataset

Mutations in superoxide dismutase 1 (SOD1) cause paralysis in familial amyotrophic lateral sclerosis and promote its misfolding into neurotoxic aggregates. Previous studies have shown that mice expressing the ALS-causing G85R variant of SOD1 develop paralysis much faster after intraspinal injection of spinal homogenates from paralyzed G85R SOD1 mice. These findings, and other studies in cell model

figshare2026 · Astronomical catalogue

<p dir="ltr">This study's data demonstrates widespread serological evidence of prior SARS-CoV-2 exposure and vaccine-induced immunity in both urban and rural Ghana. Functional neutralising antibodies were detected in a longitudinal subset, suggesting persistence of antibody-mediated protection in some individuals. Larger longitudinal studies with repeated functional immune assessments are needed t

Teesside University Research Data Repository2025 · dataset

Statistical analysis from a set of data published in the manuscript: Impact of storage on the stability and the protective effect of extracellular vesicles released by Candida albicans.

Teesside University Research Data Repository2025 · dataset

During the preparation of our manuscript, we observed that existing studies have documented a steadily increasing trend in Nocardia infections worldwide, a pattern that is expected to persist given the rising awareness and improved diagnostic techniques. To date, studies specifically focusing on the clinical and epidemiological characterization of cutaneous nocardiosis remain limited, despite its

ZivaHub + Deakin Research Online2023 · dataset

Interleukin-1 receptor-associated kinase 3 (IRAK3) modulates the magnitude of cellular responses to ligands perceived by interleukin-1 receptors (IL-1Rs) and Toll-like receptors (TLRs), leading to decreases in pro-inflammatory cytokines and suppressed inflammation. The molecular mechanism of IRAK3’s action remains unknown. IRAK3 functions as a guanylate cyclase, and its cGMP product suppresses lip

DataCite2023 · Excel spreadsheet

qRT-PCR Cellular RNA was extracted using Trizol, and total RNA (500 ng) was transcribed into cDNA using the PrimeScript kit. Actin primers were used as an internal control. Real-time fluorescence quantitative RT-PCR assays were performed using Lightcycler 480ii. The qRT-PCR primer sequences used in this study are shown below: Cacybp: forward primer: 5-CTCCCATTACAACGGGCTATAC-3, reverse primer: 5-GA